Following up on the previous post on Up, I don't mean to be the prophet of doom and gloom (listening to Miles Davis' 1975 live albums Agharta and Pangaea probably doesn't help). But if Up fails to be a huge hit at the box-office, which is to say, if this movie continues the studio's long downward trend, then it effectively marks the end. If this studio is forced to retreat creatively, trapped into making nice, safe, formulaic pictures, because that's where the money lies, then any future hope for this medium is finished.
If Pixar fails, there won't be another one to come along and take its place. What happened here was a once-in-a-lifetime event, a happy freak accident borne of a new technology. Steve Jobs' tiny studio pioneered computer animation while Hollywood slumbered, and in the process completely took over the asylum. That's never going to happen again. If Pixar fails, then this will effectively mark the end of animation as a viable artistic medium in this country.
Don't kid yourself. These are the stakes we are playing for. It's all or nothing.